The Human Upgrade with Dave Asprey

• The New Science Behind Psychedelics, Exotic Shrooms, & Daily Flow-States | Matt Zemon : 1280

  Your brain has a gear you’ve never touched. Psychedelics can shift you into it. In this episode of The Human Upgrade, Dave Asprey uncovers how high-performance psychedelic mushrooms help you access flow states, rewire your brain, and enhance clarity, energy, and emotional resilience. This is next-level biohacking rooted in real science. You will learn how to use psychedelics with intention. When to microdose. When to go deep. How to stack them with nootropics for even stronger results. Dave breaks down the latest research on psilocybin, brain plasticity, trauma release, and how to turn ancient compounds into modern performance tools. What You Will Learn in This Episode: • How psychedelic shrooms unlock flow, focus, and creative power • Why psilocybin boosts neuroplasticity, mood, and emotional healing • Microdosing vs. full-dose: what works, when, and how • How to stack psychedelics with nootropics and other biohacks • The newest research on brain optimization and long-term benefits • How to use psychedelics safely, strategically, and for real results • Why shrooms may be the strongest mental upgrade in your toolkit Thank you to our sponsors! -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Matt’s Website – https://mattzemon.com/ • Matt's Instagram - https://www.instagram.com/matt.zemon/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Trailer • 01:00 – Intro • 06:01 – Personal Psychedelic Journeys • 07:39 – Psychedelics and Self-Discovery • 11:59 – Safe Use and Smart Navigation • 29:09 – Psychedelics and Society • 36:40 – Building Trust in the Process • 37:14 – Facing Inner Fear • 37:38 – Choice and Healing • 37:51 – Diet and Conscious Decisions • 38:55 – Judgment and Relationships • 39:29 – Spirituality and Psychedelics • 40:07 – The Entheogenic Reformation • 41:29 – Past Lives and Expanded States • 43:44 – Where Science Meets Spirituality • 49:59 – Gratitude and Compassion in Healing • 01:01:47 – The Power of Apologies • 01:04:56 – Psychedelics in Therapy • 01:08:57 – Final Thoughts on Psychedelics and Culture See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  1:11:03
• Why Oral Testosterone Is the Ultimate Upgrade for Energy, Mood and Longevity (Men AND Women) | Shalin Shah : 1279

  Low testosterone is sabotaging your health, motivation, and longevity. Diet alone will not fix it. In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to expose the truth about testosterone decline in both men and women. They break down why testosterone is crashing worldwide, why natural fixes almost always fail, and how the latest science finally makes testosterone therapy safer, simpler, and more effective than ever before. You will discover why testosterone is essential for dopamine, brain function, sleep, muscle, libido, and mitochondrial health. Fixing your levels can reverse fatigue, brain fog, poor motivation, and slow aging itself. Shalin reveals how new oral testosterone technology (Kyzatrex®) overcomes the dangers of old therapies and restores natural hormone rhythms without needles, creams, or dangerous side effects. What You Will Learn in This Episode: • Why testosterone matters for men and women at every age • The real causes of the global testosterone crash • Why diet, sleep, and exercise cannot fully fix low testosterone • How testosterone drives dopamine, motivation, and longevity • The breakthrough that makes oral testosterone safe and effective • How Kyzatrex® lowers SHBG and boosts free testosterone naturally • Why maintaining youthful testosterone levels protects brain, muscle, libido, and lifespan • How to safely use testosterone therapy without suppressing fertility or causing side effects ** Visit livethrive.co/asprey to get a discount on your first month's supply! ** Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Purchase Kyzatrex® – https://livethrive.co/?utm_campaign=11813552-Asprey• Shalin’s Instagram - https://www.instagram.com/themetabolicceo/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: 00:00 Trailer 00:52 Introduction 01:29 Global Decline in Testosterone Levels 02:27 Symptoms of Low Testosterone 03:48 Personal Journey with Testosterone Therapy 05:06 The Role of Testosterone in Overall Health 06:18 Testosterone Levels in Men and Women 08:48 Challenges and Innovations in Testosterone Delivery 16:25 The Importance of Circadian Rhythm in Testosterone Therapy 19:19 The Future of Testosterone Therapy 32:00 Investment and Development in Testosterone Therapy 34:57 Introduction to FDA and Hormone Replacement 35:31 FDA’s Impact on Women’s Health 36:10 Testosterone and Cardiovascular Risk 39:05 Testosterone and Depression 40:30 Testosterone Testing and Misconceptions 44:58 The Testosterone Project and Female Hormone Therapy 47:51 Testosterone’s Role in Longevity and Health 55:37 Cost and Accessibility of Testosterone Therapy 01:04:03 Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  1:05:01
• The Deadliest Room in Your House — And How to Detox It for Better Health | Aly Cohen MD : 1278

  Your environment is rewiring your hormones, fertility, and long-term health without your consent. In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Aly Cohen, board-certified rheumatologist, integrative medicine specialist, and environmental health educator. Together they expose how common toxins in plastics, pesticides, drinking water, personal care products, and food packaging are hijacking your biology. Dr. Cohen explains how daily chemical exposures contribute to autoimmune disease, thyroid dysfunction, hormone imbalance, infertility, obesity, cancer, and accelerated aging. You will learn how to identify hidden endocrine disruptors, spot surprising sources of microplastics and PFAS (“forever chemicals”), and apply science-backed detox strategies to protect your hormones, fertility, metabolism, and longevity. What You’ll Learn in This Episode: • How chemicals in household, cleaning, and beauty products disrupt hormones • The link between environmental toxins, autoimmune disease, thyroid issues, and infertility • Hidden sources of microplastics and PFAS chemicals and how to eliminate them • Affordable, practical steps to detox your home, water, and personal care routine • Dr. Cohen’s top biohacks to protect fertility, balance hormones, and build toxin resilience THANK YOU TO OUR SPONSORS! -BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Aly’s Website – https://thesmarthuman.com/ • Aly's Website - https://alycohenmd.com/ • Aly’s New Book – Detoxify: https://alycohenmd.com/books • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: 00:00 Trailer 02:01 Introduction 02:15 Rheumatism and Rheumatology 03:36 Autoimmune Diseases and Toxins 04:17 Chemical Impact on Health 04:49 Personal Health Journey 06:15 Microplastics and Immune Disruption 08:21 Resilience and Lifestyle Changes 21:45 Nutritional Deficiencies 26:48 Lab Results and Assessments 34:40 Detoxification and Resilience 41:14 Personal Journey Continued 42:22 Clean Drinking Water 44:20 Travel Hacks for Water 46:15 Hotel Room Detox Tips 50:06 EPA Water Standards 53:06 Restaurant Toxins and Home Safety 55:36 Top Toxic Household Items 01:08:31 Synthetic Materials Impact 01:13:30 Final Thoughts and Book See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  1:12:45
• Biohacking Your Heart Health: The Life-Saving Molecule You NEED to Know | Dr. Anurag Singh : 1277

  What if you could reverse the age of your heart...without leaving home? In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal groundbreaking science that targets cardiovascular aging at the cellular level. You’ll discover how mitochondrial decline drives heart failure, why postmenopausal women face skyrocketing cardiac risks, and how one powerful molecule, Urolithin A, can rejuvenate your heart’s energy systems. Dr. Singh shares clinical research showing how Urolithin A improves mitochondrial function, boosts endurance, and may even reverse biological aging markers in the heart. You’ll also learn how simple lifestyle biohacks, combined with cellular nutrition, can protect your cardiovascular health and extend your healthspan. What You’ll Learn in This Episode: • The link between mitochondrial decline and heart failure • Why women’s cardiac risk skyrockets after menopause • How Urolithin A stimulates mitophagy and energy renewal • New human clinical data on reversing cardiac aging markers • Biohacking strategies to fortify your cardiovascular health • How to optimize endurance, recovery, and heart resilience THANK YOU TO OUR SPONSORS! -STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order. -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Timeline Website – https://www.timeline.com/partners/dave-asprey • Timeline Instagram - https://www.instagram.com/timeline_longevity/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 — Trailer • 02:11 — Supplements that help • 03:05 — Long-term benefits • 04:38 — Stacking with lifestyle • 22:19 — Heart health connection • 29:39 — Mitochondria & brain function • 33:04 — Glymphatic system & Alzheimer’s • 33:53 — Bed height & brain health • 34:18 — Why mitochondria matter • 35:43 — Inflammation & dysfunction • 38:12 — Transplants & consciousness • 39:19 — Meditation’s effects • 40:33 — The ultimate biohacking stack • 43:06 — Creatine for sleep & focus • 50:00 — Fertility insights • 57:23 — Skin health • 01:00:28 — Final thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  1:04:18
• How Laser Therapy Boosts Mood, Mental Clarity, and Consciousness with Dr. Brandon Crawford : 1276

  What if a laser could help a child speak for the first time—or reverse an “incurable” brain condition? In this episode of The Human Upgrade, Dave Asprey talks with Dr. Brandon Crawford, a leading neurotherapist and founder of 528 Innovations, about the emerging science of laser therapy for the brain and body. You’ll learn how light—when precisely pulsed and targeted—can rewire brainwaves, heal trauma, and even influence states of consciousness. Dr. Crawford explains how specific laser frequencies are being used to modulate brain states, activate the vagus nerve, improve mood, restore gut-brain communication, and support recovery from conditions like autism and ALS. From EEG shifts to structured water and mitochondrial signaling, this conversation dives deep into biohacking’s most advanced light-based tech. What You’ll Learn in This Episode: • How laser therapy rewires brainwaves for mood, focus, and clarity • The exact brain regions linked to embodiment, intuition, and flow • Why pulsing patterns matter more than power in laser tech • How light influences trauma recovery and vagus nerve activation • The role of structured water and infrared light in cellular repair • How patients with ALS and autism responded to 528 protocols ** Get 30% off GA Virtual Tickets for the Biohacking Conference this May with code ‘528i30’ at checkout! ** THANK YOU TO OUR SPONSORS! -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. -LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • 528 Innovations Website and used code ‘UPGRADE10’ at checkout – https://528innovations.com/dave • 528 Innovations Instagram - https://www.instagram.com/528innovations/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Trailer • 02:00 – Intro • 02:26 – New breakthroughs in laser therapy • 03:07 – Why laser tech needed reinvention • 04:21 – How laser light influences the brain • 08:03 – Holograms, light, and reality • 09:02 – Telepathy and autism connections • 12:03 – Rewiring the brain with light • 20:01 – Quantum signaling between cells • 22:33 – Biohacking and yogic practices • 22:54 – Testosterone and natural living • 23:37 – Boosting testosterone with lasers • 25:21 – Mitochondria and higher awareness • 27:35 – Laser benefits across the body • 30:29 – Advanced brain stimulation tech • 36:19 – ALS recovery and healing cases • 40:48 – Closing thoughts and next steps See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  40:48

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